Pre-print on a AML-associated mutation in GPR183
We demonstrate that the A338V substitution selectively alters C-terminal structural dynamics, impairing GRK2 and β-arrestin2 recruitment while preserving G protein activation. Link to the study: https://www.biorxiv.org/content/10.64898/2026.03.30.7153...
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GPR61 in severe obesity - publication in Molecular Pharmacology
We have identified and characterize mutants of GPR61 found in samples from severe obese individuals. Please see here: https://molpharm.aspetjournals.org/article/S0026-895X(25)15286-3/fulltext
Publication on GPCRs in blood cancers
In the paper, we analyze GPCR expression data in Acute Lymphoblastic Leukaemia, focusing on orphan GPCRs. Addtionally, we discuss receptors implicated or at least highly expressed in other forms of hematological cancers. Please see https://pubs.acs.org...
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