Who’s driving? Common evolutionary mechanism of activation of class A GPCRs

A. Marciniak, P. Kozielewicz, Darko Mitrovic, L. Delemotte

bioRxiv, 2026

How glycosaminoglycans mediate procathepsin K maturation: New insights from computational studies.

Damian Suchomski, P. Wesołowski, K. Bojarski

Biophysical Chemistry, 2026

Comparison of Protein–Glycosaminoglycan Interactions in ff14sb/GLYCAM06j‑1 and CHARMM36m Force Fields

K. Bojarski, P. Wesołowski, Diksha Dewan, Łukasz J. Dziadek, V. Neuman, Bernard R. Brooks, Jacek Czub, M. Zacharias, A. Sieradzan, D. J. Wales

Journal of Chemical Information and Modeling, 2026

Structure-based screening and a conformational biosensor identify a GPR183 inverse agonist and an activation switch

L. Andersson, Michele Roggia, K. Wangriatisak, Rhiannon Skye Kozel, Holly R. Brittain, Sonia Youhanna, M. Gil, Mathias Haag, V. Lauschke, Karine Chemin, Sandro Cosconati, P. Kozielewicz

Nature Communications, 2026

The AML-Associated A338V Mutation Rewires GPR183 Signaling through C-Terminal Ensemble Redistribution

L. Andersson, P. Wesołowski, Laura Jahrstorfer, Alexander De Rosa, Tomáš Heger, V. Neuman, A. Sieradzan, D. J. Wales, Paweł Kozielewicz

Journal of the American Chemical Society, 2026

Decoding the Structural and Functional Impact of the Leukaemia-Associated A338V Mutation in GPR183

L. Andersson, P. Wesołowski, Laura Jahrstorfer, Alexander De Rosa, Tomáš Heger, V. Neuman, A. Sieradzan, D. J. Wales, P. Kozielewicz

bioRxiv, 2026

Targeting the Tumor-Stroma Crosstalk: An AI-Based Virtual Screening Strategy for Dual MET/SMO Inhibitors in Pancreatic Cancer

Michele Roggia, U. Chianese, Giorgio Amendola, Valentina Albanese, Cinzia Vetrei, C. Ieranò, C. D’Alterio, S. Di Maro, F. Ciardiello, F. Morgillo, S. Scala, L. Altucci, D. Preti, Gunnar Schulte, R. Benedetti, P. Kozielewicz, Sandro Cosconati

bioRxiv, 2026

Multiscale frameworks for exploring protein energy landscapes: advances in theory and simulation

P. Wesołowski

Journal of biological physics (Print), 2026

Visualizing the energy landscape for a molecular dynamics trajectory.

V. Neuman, P. Wesołowski, K. Bojarski, Diksha Dewan, Moritz Schäffler, Pamela Smardz, D. J. Wales

Journal of Chemical Physics, 2026

Identification and molecular characterization of missense mutations in orphan G protein–coupled receptor GPR61 occurring in severe obesity

Choi Har Tsang, Alexander De Rosa, Pawel Kozielewicz

Molecular Pharmacology, vol. 107(4), 2025

Class Frizzled GPCRs in GtoPdb v.2025.3

E. Arthofer, Jana Valnohova, Kateřina Straková, Gunnar Schulte, Tilman Polonio, J. Petersen, Jessica Olofsson, Matthias Lauth, P. Kozielewicz, Julia Kinsolving, B. Hot, Lukas Grätz, J. Dijksterhuis, Shane C. Wright

IUPHAR/BPS Guide to Pharmacology CITE, 2025

AI-Driven Virtual Screening and First-in-Class Conformational Biosensor Enable the Discovery of a GPR183 Inverse Agonist

Louise Andersson, Michele Roggia, K. Wangriatisak, Maria Gil, Karine Chemin, Sandro Cosconati, P. Kozielewicz

bioRxiv, 2025

SAG1.3-derived Frizzled-targeting small-molecule compounds

Lukas Grätz, Ainoleena Turku, P. Kozielewicz, Carl-Fredrik Bowin, Magdalena M. Scharf, J. Voss, Julia Kinsolving, Rawan Shekhani, Nuria Oliva-Vilarnau, Tobias Koolmeister, Marlies Körber, V. Lauschke, S. Löber, Peter Gmeiner, Gunnar Schulte

Journal of Biological Chemistry, 2025

Benchmark of Available Explicit Solvent Models in CHARMM36m to Characterize Glycosaminoglycans

P. Wesołowski, D. J. Wales, K. Bojarski

Journal of Physical Chemistry B, 2025

The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors

S. P. Alexander, A. P. Davenport, E. Kelly, Alasdair J Gibb, A. Mathie, Chloe J. Peach, E. Veale, J. Armstrong, E. Faccenda, S. Harding, C. Southan, J. Davies, M. Abbracchio, George R. Abraham, Alexander I. Agoulnik, Wayne Alexander, K. Al‐Hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross A. D. Bathgate, Jean‐Martin Beaulieu, Annette G. Beck-Sickinger, Maik Behrens, K. Bennett, Kenneth E. Bernstein, B. Bettler, Nigel J. M. Birdsall, V. Blaho, P. Bonaventure, Franc¸ois Boulay, Corinne Bousquet, Hans Bräuner-Osborne, Andrew J. Brown, G. Burnstock, Marta Busnelli, Girolamo Calo', Vanni Caruso, Justo P. Castaño, K. J. Catt, S. Ceruti, P. Chazot, Chia Nan, B. Chini, A. Christopoulos, Jerold Chun, A. Cianciulli, Olivier Civelli, L. Clapp, Réjean Couture, Helen M. Cox, Z. Csaba, Claes Dahlgren, F. Dautzenberg, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Margarita L. Dubocovich, Satoru Eguchi, Emanuel Escher, E. Filardo, Tung M. Fong, H. Forsman, M. Fumagalli, R. Gainetdinov, Michael L. Garelja, Marc Gasparo, Florence Gbahou, C. Gerard, M. Gershengorn, Michelle Glass, David E. Gloriam, Fernand Junior Gobeil, T. Goodfriend, C. Goudet, Lukas Grätz, K. Gregory, Christian J. Gruber, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Deborah S. Hartman, R. Hauger, Deborah L. Hay, A. Heinemann, L. Heitman, D. Herr, M. Hollenberg, Nicholas D. Holliday, Birgitte Holst, M. Horiuchi, D. Hoyer, László Hunyady, Ahsan Husain, A. P. Ijzerman, Tadashi Inagami, Paul A. Insel, K. Jacobson, Laura H. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, K. Kaupmann, Jacqueline R. Kemp, Charles Kennedy, Yasuyuki Kihara, Julia Kinsolving, Takio Kitazawa, Paweł Kozielewicz, H. Kreienkamp, J. Kukkonen, Luxmichan Laishram, Tobias Langenhan, C. Langmead, Dan Larhammar, K. Leach, D. Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, R. Leurs, Xaria X. Li, Ines Liebscher, S. Lolait, Amelie Lupp, Robyn G. C. Macrae, Janet J. Maguire, D. Malfacini, Maurice Manning, Davide Marangon, Kirill A. Martemyanov, Jean Mazella, C. McArdle, S. Melmed, Martin C. Michel, Laurence J. Miller, V. Mitolo, Bernard Mouillac, Christa E. Müller, P. Murphy, J. Nahon, R. Neubig, Tony Ngo, Xavier Norel, Duuamene Nyimanu, A. O'Carroll, S. Offermanns, M. Panaro, M. Parmentier, Nicole A. Perry-Hauser, R. Pertwee, Jean-Philippe Pin, E. Prossnitz, Helena Chengxue Qin, Mark Quinn, S. Raffaele, R. Ramachandran, Manisha Ray, R. Reinscheid, Alejandro Romeral Buzón, P. Rondard, M. Rosenkilde, G. Rovati, C. Ruzza, Gareth J. Sanger, N. Scholz, Torsten Schöneberg, G. Schulte, Stefan Schulz, Deborah Segaloff, Charles N. Serhan, Arun K. Shukla, K. D. Singh, Craig M. Smith, Nicola J Smith, C. Stäubert, Leigh A. Stoddart, Yukihiko Sugimoto, Roger J. Summers, Valerie P. Tan, D. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan C. Tirupula, L. Toll, G. Tulipano, Hamiyet Unal, T. Unger, C. Valant, P. Vanderheyden, D. Vaudry, H. Vaudry, Joseph G. Verbalis, J. Vilardaga, Christopher Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, G. Willars, T. Williams, Trent M. Woodruff, Huixian Wu, Cheng Yang, Chengcan Yao, Richard D. Ye, Nathan A. Zaidman

British Journal of Pharmacology, 2025

New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer.

C. Espinosa-Bustos, J. Bertrand, Alondra Villegas-Menares, Simón Guerrero, L. Di Marcotullio, Shirin Navacci, Gunnar Schulte, P. Kozielewicz, Nicolas Bloch, Valentina Villela, Margot Paulino, Marcelo J. Kogan, Jorge Cantero, Cristian O Salas

Bioorganic chemistry (Print), 2024

Exploring G Protein-Coupled Receptors in Hematological Cancers.

Choi Har Tsang, P. Kozielewicz

ACS Pharmacology & Translational Science, 2024

Frizzleds act as dynamic pharmacological entities.

Gunnar Schulte, Magdalena M. Scharf, J. Bous, Jan Hendrik Voss, Lukas Grätz, P. Kozielewicz

TIPS - Trends in Pharmacological Sciences, 2024

Application of FRET- and BRET-based live-cell biosensors in deorphanization and ligand discovery studies on orphan G protein-coupled receptors.

Joanna J. Sajkowska, Choi Har Tsang, P. Kozielewicz

SLAS discovery : advancing life sciences R & D, 2024

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7.

Julia Kinsolving, Julien Bous, P. Kozielewicz, Sara Košenina, Rawan Shekhani, Lukas Grätz, G. Masuyer, Yuankai Wang, P. Stenmark, Min Dong, Gunnar Schulte

Cell Reports, 2024

Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling

Krzysztof Wierbiłowicz, Chun-Song Yang, Ahmed Almaghasilah, P. Wesołowski, Philipp Pracht, Natalia M. Dworak, Jack Masur, Sven Wijngaarden, Dmitri V. Filippov, David J. Wales, Joshua B. Kelley, A. Ratan, B. Paschal

bioRxiv, 2024

Progress on the development of Class A GPCR‐biased ligands

Paula Morales, Magdalena M Scharf, Marcel Bermúdez, Attila Egyed, Rafael Franco, O. K. Hansen, Nadine Jagerovic, Jan Jakubík, G. Keserű, Dóra Judit Kiss, P. Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo-Abreu, Gemma Navarro, Rubén Prieto-Díaz, M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, L. Wingler

British Journal of Pharmacology, 2024

Progress on the development of Class A GPCR-biased ligands.

Paula Morales, Magdalena M Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K Hansen, Nadine Jagerovic, Jan Jakubík, György M Keserű, Dóra Judit Kiss, P. Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo-Abreu, Gemma Navarro, Rubén Prieto-Díaz, M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, L. Wingler

British Journal of Pharmacology, 2024

CREST-A program for the exploration of low-energy molecular chemical space.

Philipp Pracht, S. Grimme, C. Bannwarth, Fabian Bohle, S. Ehlert, Gereon Feldmann, Johannes Gorges, Marcel Müller, Tim Neudecker, Christoph Plett, S. Spicher, Pit Steinbach, P. Wesołowski, Felix Zeller

Journal of Chemical Physics, 2024

Multilevel Framework for Analysis of Protein Folding Involving Disulfide Bond Formation

P. Wesołowski, D. J. Wales, Philipp Pracht

Journal of Physical Chemistry B, 2024

WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction

Carl-Fredrik Bowin, P. Kozielewicz, Lukas Grätz, Maria Kowalski-Jahn, Hannes Schihada, G. Schulte

Science Signaling, 2023

Class Frizzled GPCRs in GtoPdb v.2023.1 Class Frizzled GPCRs in GtoPdb v.2023.1

E. Arthofer, J. Dijksterhuis, Lukas Grätz, B. Hot, P. Kozielewicz, M. Lauth, J. Olofsson, J. Petersen, Tilman Polonio, G. Schulte, Kateřina Straková, Jana Valnohova, Shane C. Wright

2023

NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model.

Lukas Grätz, J. J. Sajkowska-Kozielewicz, Janine Wesslowski, Julia Kinsolving, L. Bridge, Katja Petzold, G. Davidson, G. Schulte, P. Kozielewicz

British Journal of Pharmacology, 2023

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations

Lukas Grätz, Maria Kowalski-Jahn, Magdalena M. Scharf, P. Kozielewicz, Michael Jahn, J. Bous, N. Lambert, D. Gloriam, G. Schulte

Nature Communications, 2023

Energy landscapes for proteins described by the UNRES coarse-grained potential.

P. Wesołowski, A. Sieradzan, Michal J. Winnicki, John W. R. Morgan, D. J. Wales

Biophysical Chemistry, 2023

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Stephen P H Alexander, A. Christopoulos, Anthony P Davenport, E. Kelly, A. Mathie, John A Peters, E. Veale, J. Armstrong, E. Faccenda, S. Harding, J. Davies, M. Abbracchio, George Abraham, Alexander Agoulnik, Wayne Alexander, Khaled A. Al‐Hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross A. D. Bathgate, Jean‐Martin Beaulieu, Annette G. Beck-Sickinger, Maik Behrens, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, V. Blaho, Franc¸ois Boulay, Corinne Bousquet, H. Bräuner‐Osborne, Geoffrey Burnstock, Girolamo Calo’, Justo P. Castaño, K. J. Catt, S. Ceruti, P. Chazot, Chia Nan, Bice Chini, Jerold Chun, A. Cianciulli, Olivier Civelli, L. Clapp, Réjean Couture, Helen M. Cox, Z. Csaba, Claes Dahlgren, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, E. Filardo, Tung Fong, M. Fumagalli, R. Gainetdinov, Michael L Garelja, Marc Gasparo, Craig Gerard, M. Gershengorn, Fernand Junior Gobeil, T. Goodfriend, C. Goudet, Lukas Grätz, K. Gregory, A. L. Gundlach, Jörg Hamann, Julien Hanson, R. Hauger, Deborah L. Hay, A. Heinemann, D. Herr, M. Hollenberg, N. Holliday, M. Horiuchi, D. Hoyer, László Hunyady, Ahsan Husain, A. P. IJzerman, Tadashi Inagami, Kenneth A. Jacobson, R. Jensen, Ralf Jockers, Deepa Jonnalagadda, S. Karnik, K. Kaupmann, Jacqueline R. Kemp, Charles Kennedy, Yasuyuki Kihara, Takio Kitazawa, Paweł Kozielewicz, H. Kreienkamp, J. Kukkonen, T. Langenhan, D. Larhammar, K. Leach, D. Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Xaria X. Li, S. Lolait, A. Lupp, Robyn G. C. Macrae, J. Maguire, D. Malfacini, J. Mazella, C. McArdle, S. Melmed, Martin C. Michel, Laurence J. Miller, V. Mitolo, B. Mouillac, Christa E. Müller, P. M. Murphy, J. Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, A. O'Carroll, Stefan Offermanns, M. Panaro, Marc Parmentier, R. Pertwee, Jean-Philippe Pin, E. Prossnitz, Mark T. Quinn, R. Ramachandran, Manisha Ray, R. Reinscheid, P. Rondard, G. Rovati, C. Ruzza, Gareth J Sanger, Torsten Schöneberg, G. Schulte, Stefan Schulz, D. Segaloff, Charles N. Serhan, K. D. Singh, Craig M. Smith, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie Tan, D. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan C. Tirupula, L. Toll, G. Tulipano, Hamiyet Unal, Thomas Unger, C. Valant, P. Vanderheyden, D. Vaudry, H. Vaudry, J. Vilardaga, Christopher Walker, Ji Ming Wang, Donald T. Ward, Hans-Juergen Wester, G. Willars, Tom Lloyd Williams, Trent M. Woodruff, Chengcan Yao, Richard D. Ye

British Journal of Pharmacology, 2023

On the need to introduce environmental characteristics in ab initio protein structure prediction using a coarse-grained UNRES force field.

I. Roterman, A. Sieradzan, K. Stapor, P. Fabian, P. Wesołowski, L. Konieczny

Journal of Molecular Graphics and Modelling, 2022

NanoBRET and NanoBiT/BRET-Based Ligand Binding Assays Permit Quantitative Assessment of Small Molecule Ligand Binding to Smoothened.

P. Kozielewicz, G. Schulte

Methods in molecular biology, 2022

Residue 6.43 defines receptor function in class F GPCRs

Ainoleena Turku, Hannes Schihada, P. Kozielewicz, Carl-Fredrik Bowin, G. Schulte

Nature Communications, 2021

Coarse-grained modeling of the calcium, sodium, magnesium and potassium cations interacting with proteins

A. Lipska, Anna Antoniak, P. Wesołowski, Alan Warszawski, S. Samsonov, A. Sieradzan

Journal of Molecular Modeling, 2021

Modeling protein structures with the coarse-grained UNRES force field in the CASP14 experiment.

Anna Antoniak, Iga Biskupek, K. Bojarski, C. Czaplewski, A. Giełdoń, Mateusz Kogut, M. Kogut, P. Krupa, A. Lipska, A. Liwo, E. Lubecka, M. Marcisz, M. Maszota-Zieleniak, S. Samsonov, A. Sieradzan, M. Ślusarz, R. Ślusarz, P. Wesołowski, Karolina Zieba

Journal of Molecular Graphics and Modelling, 2021

Extension of the Unres Package for Physics-Based Coarse-Grained Simulations of Proteins and Protein Complexes to Very Large Systems

A. Sieradzan, C. Czaplewski, E. Lubecka, A. Lipska, Agnieszka S. Karczynska, A. Giełdoń, R. Ślusarz, M. Makowski, P. Krupa, Mateusz Kogut, Anna Antoniak, P. Wesołowski, A. Augustynowicz, H. Leszczynski, J. Liwo

2021

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs

Lu Xu, Bo Chen, Hannes Schihada, Shane C. Wright, Ainoleena Turku, Yiran Wu, G. Han, Maria Kowalski-Jahn, P. Kozielewicz, Carl-Fredrik Bowin, Xianjun Zhang, Chao Li, M. Bouvier, G. Schulte, Fei Xu

Cell Research, 2021

Prediction of protein assemblies, the next frontier: The CASP14-CAPRI experiment

M. Lensink, G. Brysbaert, Théo Mauri, Nurul Nadzirin, S. Velankar, Raphael A. G. Chaleil, Tereza Clarence, P. Bates, Ren Kong, Bin Liu, Guangbo Yang, Ming Liu, Hang Shi, Xufeng Lu, Shan Chang, Rajashree Roy, Farhan Quadir, Jian Liu, Jian-Lin Cheng, Anna Antoniak, C. Czaplewski, A. Giełdoń, Mateusz Kogut, A. Lipska, A. Liwo, E. Lubecka, M. Maszota-Zieleniak, A. Sieradzan, R. Ślusarz, P. Wesołowski, Karolina Zieba, C. A. Del Carpio Munoz, E. Ichiishi, Ameya Harmalkar, Jeffrey J. Gray, A. Bonvin, Francesco Ambrosetti, R. Honorato, Z. Jandova, Brian Jiménez-García, Panagiotis I. Koukos, S. V. van Keulen, Charlotte van Noort, M. Réau, Jorge Roel‐Touris, S. Kotelnikov, D. Padhorny, Kathryn A. Porter, Andrey Alekseenko, Mikhail Ignatov, Israel T. Desta, Ryota Ashizawa, Zhuyezi Sun, Usman Ghani, Nasser Hashemi, S. Vajda, D. Kozakov, Mireia Rosell, L. A. Rodríguez-Lumbreras, J. Fernández-Recio, Agnieszka S. Karczynska, Sergei Grudinin, Yumeng Yan, Hao Li, Peicong Lin, Sheng-You Huang, Charles W Christoffer, Genki Terashi, Jacob Verburgt, Daipayan Sarkar, Tunde Aderinwale, Xiao Wang, D. Kihara, Tsukasa Nakamura, Y. Hanazono, R. Gowthaman, Johnathan D. Guest, Rui Yin, G. Taherzadeh, B. Pierce, Didier Barradas-Bautista, Zhen Cao, L. Cavallo, R. Oliva, Yuan-Fei Sun, Shaowen Zhu, Yang Shen, Taeyong Park, Hyeonuk Woo, Jinsol Yang, Sohee Kwon, Jonghun Won, Chaok Seok, Yasuomi Kiyota, S. Kobayashi, Yoshiki Harada, Mayuko Takeda-Shitaka, P. Kundrotas, Amar Singh, I. Vakser, J. Dapkūnas, K. Olechnovič, Č. Venclovas, R. Duan, Liming Qiu, Shuang Zhang, Xiaoqin Zou, S. Wodak

Proteins: Structure, Function, and Bioinformatics, 2021

Author response for "Prediction of protein assemblies, the next frontier: The CASP14‐CAPRI experiment"

M. Lensink, Guillaume Brysbaert, Théo Mauri, Nurul Nadzirin, S. Velankar, Raphael A. G. Chaleil, Tereza Clarence, P. Bates, Ren Kong, Bin Liu, Guangbo Yang, Ming Liu, Hang Shi, Xufeng Lu, Shan Chang, Rajashree Roy, Farhan Quadir, Jian Liu, Jian-Lin Cheng, Anna Antoniak, C. Czaplewski, Artur Giełdoń, Mateusz Kogut, Agnieszka G. Lipska, Adam Liwo, Emilia A. Lubecka, Martyna Maszota-Zieleniak, A. Sieradzan, R. Ślusarz, P. Wesołowski, Karolina Zieba, C. A. Del Carpio Munoz, E. Ichiishi, Ameya Harmalkar, Jeffrey J. Gray, A. Bonvin, Francesco Ambrosetti, R. Honorato, Zuzana Jandova, Brian Jiménez-García, Panagiotis I. Koukos, S. V. van Keulen, Charlotte van Noort, Manon Réau, Jorge Roel-Touris, S. Kotelnikov, Dzmitry Padhorny, Kathryn A. Porter, Andrey Alekseenko, Mikhail Ignatov, Israel T. Desta, Ryota Ashizawa, Zhuyezi Sun, Usman Ghani, Nasser Hashemi, S. Vajda, D. Kozakov, Mireia Rosell, Luis A. Rodríguez-Lumbreras, J. Fernández-Recio, Agnieszka Karczynska, Sergei Grudinin, Yupu Yan, Hao Li, Peicong Lin, Sheng-You Huang, Charles Christoffer, Genki Terashi, Jacob Verburgt, Daipayan Sarkar, Tunde Aderinwale, Xiao Wang, D. Kihara, Tsukasa Nakamura, Y. Hanazono, Ragul Gowthaman, Johnathan D. Guest, Rui Yin, Ghazaleh Taherzadeh, B. Pierce, Didier Barradas-Bautista, Zhen Cao, Luigi Cavallo, R. Oliva, Yuan-Fei Sun, Shaowen Zhu, Yang Shen, Taeyong Park, Hyeonuk Woo, Jinsol Yang, Sohee Kwon, Jonghun Won, Chaok Seok, Yasuomi Kiyota, S. Kobayashi, Yoshiki Harada, Mayuko Takeda-Shitaka, P. Kundrotas, Amar Singh, I. Vakser, Justas Dapkūnas, K. Olechnovič, Č. Venclovas, R. Duan, Li-Ming Qiu, Shuang Zhang, Xiao-Qing Zou, S. Wodak

2021

Employing Genetically Encoded, Biophysical Sensors to Understand WNT/Frizzled Interaction and Receptor Complex Activation.

P. Kozielewicz, Hannes Schihada, G. Schulte

Handbook of Experimental Pharmacology, 2021

Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments

P. Kozielewicz, Rawan Shekhani, Stefanie Moser, Carl-Fredrik Bowin, Janine Wesslowski, G. Davidson, G. Schulte

ACS Pharmacology & Translational Science, 2021

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Stephen P. H. Alexander, A. Christopoulos, A. Davenport, E. Kelly, A. Mathie, J. A. Peters, E. Veale, J. Armstrong, E. Faccenda, S. Harding, Adam J. Pawson, C. Southan, J. Davies, M. Abbracchio, Wayne Alexander, Khaled Al-hosaini, M. Bäck, N. Barnes, R. Bathgate, J. Beaulieu, K. Bernstein, B. Bettler, N. Birdsall, V. Blaho, F. Boulay, C. Bousquet, H. Bräuner‐Osborne, G. Burnstock, G. Calo’, J. Castaño, K. Catt, S. Ceruti, P. Chazot, N. Chiang, B. Chini, J. Chun, A. Cianciulli, O. Civelli, L. Clapp, R. Couture, Z. Csaba, C. Dahlgren, G. Dent, K. D. Singh, S. Douglas, P. Dournaud, S. Eguchi, E. Escher, E. Filardo, T. Fong, M. Fumagalli, R. Gainetdinov, M. Gasparo, C. Gerard, M. Gershengorn, F. Gobeil, T. Goodfriend, C. Goudet, K. Gregory, A. Gundlach, J. Hamann, J. Hanson, R. Hauger, D. Hay, A. Heinemann, M. Hollenberg, N. Holliday, M. Horiuchi, D. Hoyer, L. Hunyady, A. Husain, A. IJzerman, T. Inagami, K. Jacobson, R. Jensen, R. Jockers, Deepa Jonnalagadda, S. Karnik, K. Kaupmann, Jacqueline R. Kemp, C. Kennedy, Y. Kihara, T. Kitazawa, P. Kozielewicz, H. Kreienkamp, J. Kukkonen, T. Langenhan, K. Leach, D. Lecca, John D. Lee, S. Leeman, J. Leprince, Xaria X. Li, Thomas L. Williams, S. Lolait, A. Lupp, Robyn G. C. Macrae, J. Maguire, J. Mazella, C. McArdle, S. Melmed, M. Michel, L. Miller, V. Mitolo, B. Mouillac, C. Müller, Philip Murphy, J. Nahon, T. Ngo, X. Norel, Duuamene Nyimanu, A. O'Carroll, S. Offermanns, M. Panaro, M. Parmentier, R. Pertwee, J. Pin, E. Prossnitz, M. Quinn, R. Ramachandran, Manisha Ray, R. Reinscheid, P. Rondard, G. Rovati, C. Ruzza, G. Sanger, T. Schöneberg, G. Schulte, S. Schulz, D. Segaloff, C. Serhan, Leigh A. Stoddart, Y. Sugimoto, R. Summers, V. P. Tan, D. Thal, Walters Thomas, P. Timmermans, Kalyan C. Tirupula, G. Tulipano, Hamiyet Unal, T. Unger, C. Valant, P. Vanderheyden, D. Vaudry, H. Vaudry, J. Vilardaga, C. Walker, Ji Ming Wang, D. Ward, H. Wester, G. Willars, T. Woodruff, Chengcan Yao, R. Ye

British Journal of Pharmacology, 2021

Mitochondrial protein biogenesis in the synapse is supported by local translation

Bożena Kuźniewska, D. Cysewski, Michał Wasilewski, Paulina Sakowska, J. Miłek, Tomasz M. Kuliński, M. Winiarski, P. Kozielewicz, E. Knapska, M. Dadlez, A. Chacińska, A. Dziembowski, M. Dziembowska

EMBO Reports, 2020

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

Janine Wesslowski, P. Kozielewicz, Xianxian Wang, Haijun Cui, Hannes Schihada, Dominique Kranz, Pradhipa Karuna M, P. Levkin, J. Gross, M. Boutros, G. Schulte, G. Davidson

Journal of Biological Chemistry, 2020

Geissospermiculatine, a New Alkaloid from Geissospermum reticulatum Bark

J. J. Sajkowska-Kozielewicz, P. Kozielewicz, K. Makarova, Marcin Stocki, N. Barnes, K. Paradowska

Molecules, 2020

Structural insight into small molecule action on Frizzleds

P. Kozielewicz, Ainoleena Turku, Carl-Fredrik Bowin, J. Petersen, J. Valnohova, Maria Consuelo Alonso Cañizal, Yuki Ono, A. Inoue, C. Hoffmann, G. Schulte

Nature Communications, 2020

Molecular Pharmacology of Class F Receptor Activation

P. Kozielewicz, Ainoleena Turku, G. Schulte

Molecular Pharmacology, 2020

Mitochondria biogenesis in the synapse is supported by local translation

Bożena Kuźniewska, D. Cysewski, Michał Wasilewski, Paulina Sakowska, J. Miłek, Tomasz M. Kuliński, P. Kozielewicz, M. Dadlez, A. Chacińska, A. Dziembowski, M. Dziembowska

bioRxiv, 2019

Structural insight into Class F receptors - What have we learnt regarding agonist-induced activation?

G. Schulte, P. Kozielewicz

Basic & Clinical Pharmacology & Toxicology, 2019

Comment on: Triazoles bind the C-terminal domain of SMO: Illustration by docking and molecular dynamics simulations the binding between SMO and triazoles.

P. Kozielewicz

Life Science, 2019

A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine

P. Kozielewicz, Carl-Fredrik Bowin, Ainoleena Turku, G. Schulte

Molecular Pharmacology, 2019

Overexpression of Orphan Receptor GPR61 Increases cAMP Levels upon Forskolin Stimulation in HEK293 Cells: in vitro and in silico Validation of 5-(Nonyloxy)Tryptamine as a Low-Affinity Inverse Agonist

P. Kozielewicz, G. Grafton, J. J. Sajkowska-Kozielewicz, N. Barnes

Pharmacology, 2019

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

Shane C. Wright, P. Kozielewicz, Maria Kowalski-Jahn, J. Petersen, Carl-Fredrik Bowin, G. Slodkowicz, M. Marti-Solano, D. Rodríguez, B. Hot, Najeah Okashah, Kateřina Straková, J. Valnohova, M. Madan Babu, N. Lambert, Jens Carlsson, G. Schulte

Nature Communications, 2019

Naphthalene Peri Annelated N,N- and N,O-Heterocycles: The Effect of Heteroatom-Guided Peri -Fusion on Their Structure and Reactivity Profiles-A Theoretical Endoscopy

Demeter Tzeli, P. Kozielewicz, M. Zloh, Dyeison Antonow, P. Tsoungas, I. Petsalakis

ChemistrySelect, 2018

Intramolecular single H bonding vs bifurcation in tuning the conformation of 2,2′-dihydroxybenzophenone and its derivatives: a DFT insight

Demeter Tzeli, P. Tsoungas, I. Petsalakis, P. Kozielewicz

Structural Chemistry, 2017

N‐glycosylation and expression in human tissues of the orphan GPR61 receptor

P. Kozielewicz, Hatun A. Alomar, Syaratul Yusof, G. Grafton, A. Cooper, S. Curnow, J. Ironside, H. Pall, N. Barnes

FEBS Open Bio, 2017

2, 2′‐Dihydroxybenzophenones and Derivatives. Efficient Synthesis and Structure Endoscopy by DFT and NMR. Credentials as Potent Antiinflammatory Agents.

Demeter Tzeli, P. Kozielewicz, M. Zervou, C. Potamitis, Katerina Kokkotou, Benedikt Rak, A. Petrou, E. Tsolaki, A. Gavalas, A. Geronikaki, I. Petsalakis, P. Tsoungas

2016

Analysis of impact of cytotoxic and antioxidant activities of the Jerusalem Balsams using chemometric methods

JJ Sajkowska-Kozielewicz, P. Kozielewicz, K. Makarova, I. Wawer, K. Paradowska

Planta Medica, 2016

Antioxidant, Cytotoxic, and Antiproliferative Activities and Total Polyphenol Contents of the Extracts of Geissospermum reticulatum Bark

J. J. Sajkowska-Kozielewicz, P. Kozielewicz, N. Barnes, I. Wawer, K. Paradowska

Oxidative Medicine and Cellular Longevity, 2016

Cytotoxic, anti-radical and reducing properties of ethanol bark extracts of Geissospermum reticulatum

JJ Sajkowska-Kozielewicz, P. Kozielewicz, NM Barnes, I. Wawer, K. Paradowska

Planta Medica, 2016

Novel vitamin D analogues; cytotoxic and anti-proliferative activity against a diffuse large B-cell lymphoma cell line and B-cells from healthy donors

Paweł Kozielewicz, G. Grafton, A. Kutner, S. Curnow, J. Gordon, Nicholas M. Barnes, Paweł Kozielewicz, S. Curnow

Journal of Steroid Biochemistry and Molecular Biology, 2016

Intramolecular cyclization of β-nitroso-o-quinone methides: a theoretical endoscopy of a potentially useful innate ‘reclusive’ reaction

Demeter Tzeli, P. Tsoungas, I. Petsalakis, P. Kozielewicz, M. Zloh

2015

Arene-fused 1,2-oxazole N-oxides and derivatives. The impact of the N–O dipole and substitution on their aromatic character and reactivity profile. Can it be a useful structure in synthesis? A theoretical insight

P. Kozielewicz, Demeter Tzeli, P. Tsoungas, M. Zloh

Structural Chemistry, 2014

Insights into mechanism of anticancer activity of pentacyclic oxindole alkaloids of Uncaria tomentosa by means of a computational reverse virtual screening and molecular docking approach

P. Kozielewicz, K. Paradowska, Slavica Erić, I. Wawer, M. Zloh

Chemical Monthly, 2014

β-Nitroso-o-quinone methides: potent intermediates in organic chemistry and biology. The impact of the NO group on their structure and reactivity profile: a theoretical insight

P. Kozielewicz, P. Tsoungas, Demeter Tzeli, I. Petsalakis, M. Zloh

Structural Chemistry, 2014