https://www.kozielewicz.com https://www.kozielewicz.com/publications https://www.kozielewicz.com/projects https://www.kozielewicz.com/people https://www.kozielewicz.com/courses https://www.kozielewicz.com/posts https://www.kozielewicz.com/pages https://www.kozielewicz.com/cv https://www.kozielewicz.com/contact_form https://www.kozielewicz.com/publications/47694-identification-and-molecular-characterization-of-missense-mutations-in-orphan-g-protein-coupled-receptor-gpr61-occurring-in-severe-obesity https://www.kozielewicz.com/publications/56674-class-frizzled-gpcrs-in-gtopdb-v-2025-3 https://www.kozielewicz.com/publications/56673-ai-driven-virtual-screening-and-first-in-class-conformational-biosensor-enable-the-discovery-of-a-gpr183-inverse-agonist https://www.kozielewicz.com/publications/56672-sag1-3-derived-frizzled-targeting-small-molecule-compounds https://www.kozielewicz.com/publications/35783-new-smoothened-ligands-based-on-the-purine-scaffold-as-potential-agents-for-treating-pancreatic-cancer https://www.kozielewicz.com/publications/41552-exploring-g-protein-coupled-receptors-in-hematological-cancers https://www.kozielewicz.com/publications/34992-frizzleds-act-as-dynamic-pharmacological-entities https://www.kozielewicz.com/publications/35784-application-of-fret-and-bret-based-live-cell-biosensors-in-deorphanization-and-ligand-discovery-studies-on-orphan-g-protein-coupled-receptors https://www.kozielewicz.com/publications/29986-structural-and-functional-insight-into-the-interaction-of-clostridioides-difficile-toxin-b-and-fzd7 https://www.kozielewicz.com/publications/47690-progress-on-the-development-of-class-a-gpcr-biased-ligands https://www.kozielewicz.com/publications/38250-progress-on-the-development-of-class-a-gpcr-biased-ligands https://www.kozielewicz.com/publications/27128-wnt-stimulation-induces-dynamic-conformational-changes-in-the-frizzled-dishevelled-interaction https://www.kozielewicz.com/publications/38251-class-frizzled-gpcrs-in-gtopdb-v-2023-1-class-frizzled-gpcrs-in-gtopdb-v-2023-1 https://www.kozielewicz.com/publications/27129-nanobit-and-nanobit-bret-based-assays-allow-the-analysis-of-binding-kinetics-of-wnt-3a-to-endogenous-frizzled-7-in-a-colorectal-cancer-model https://www.kozielewicz.com/publications/27127-pathway-selectivity-in-frizzleds-is-achieved-by-conserved-micro-switches-defining-pathway-determining-active-conformations https://www.kozielewicz.com/publications/28750-the-concise-guide-to-pharmacology-2023-24-g-protein-coupled-receptors https://www.kozielewicz.com/publications/27131-nanobret-and-nanobit-bret-based-ligand-binding-assays-permit-quantitative-assessment-of-small-molecule-ligand-binding-to-smoothened https://www.kozielewicz.com/publications/27133-residue-6-43-defines-receptor-function-in-class-f-gpcrs https://www.kozielewicz.com/publications/27135-cryo-em-structure-of-constitutively-active-human-frizzled-7-in-complex-with-heterotrimeric-gs https://www.kozielewicz.com/publications/27132-employing-genetically-encoded-biophysical-sensors-to-understand-wnt-frizzled-interaction-and-receptor-complex-activation https://www.kozielewicz.com/publications/27136-quantitative-profiling-of-wnt-3a-binding-to-all-human-frizzled-paralogues-in-hek293-cells-by-nanobit-bret-assessments https://www.kozielewicz.com/publications/27134-the-concise-guide-to-pharmacology-2021-22-g-protein-coupled-receptors https://www.kozielewicz.com/publications/27140-mitochondrial-protein-biogenesis-in-the-synapse-is-supported-by-local-translation https://www.kozielewicz.com/publications/27138-egfp-tagged-wnt-3a-enables-functional-analysis-of-wnt-trafficking-and-signaling-and-kinetic-assessment-of-wnt-binding-to-full-length-frizzled https://www.kozielewicz.com/publications/27139-geissospermiculatine-a-new-alkaloid-from-geissospermum-reticulatum-bark https://www.kozielewicz.com/publications/27137-structural-insight-into-small-molecule-action-on-frizzleds https://www.kozielewicz.com/publications/27141-molecular-pharmacology-of-class-f-receptor-activation https://www.kozielewicz.com/publications/28749-mitochondria-biogenesis-in-the-synapse-is-supported-by-local-translation https://www.kozielewicz.com/publications/27144-structural-insight-into-class-f-receptors-what-have-we-learnt-regarding-agonist-induced-activation https://www.kozielewicz.com/publications/27142-comment-on-triazoles-bind-the-c-terminal-domain-of-smo-illustration-by-docking-and-molecular-dynamics-simulations-the-binding-between-smo-and-triazoles https://www.kozielewicz.com/publications/27147-a-nanobret-based-binding-assay-for-smoothened-allows-real-time-analysis-of-ligand-binding-and-distinction-of-two-binding-sites-for-bodipy-cyclopamine https://www.kozielewicz.com/publications/27146-overexpression-of-orphan-receptor-gpr61-increases-camp-levels-upon-forskolin-stimulation-in-hek293-cells-in-vitro-and-in-silico-validation-of-5-nonyloxy-tryptamine-as-a-low-affinity-inverse-agonist https://www.kozielewicz.com/publications/27145-a-conserved-molecular-switch-in-class-f-receptors-regulates-receptor-activation-and-pathway-selection https://www.kozielewicz.com/publications/27148-naphthalene-peri-annelated-n-n-and-n-o-heterocycles-the-effect-of-heteroatom-guided-peri-fusion-on-their-structure-and-reactivity-profiles-a-theoretical-endoscopy https://www.kozielewicz.com/publications/27150-intramolecular-single-h-bonding-vs-bifurcation-in-tuning-the-conformation-of-2-2-dihydroxybenzophenone-and-its-derivatives-a-dft-insight https://www.kozielewicz.com/publications/27149-n-glycosylation-and-expression-in-human-tissues-of-the-orphan-gpr61-receptor https://www.kozielewicz.com/publications/27153-2-2-dihydroxybenzophenones-and-derivatives-efficient-synthesis-and-structure-endoscopy-by-dft-and-nmr-credentials-as-potent-antiinflammatory-agents https://www.kozielewicz.com/publications/28753-analysis-of-impact-of-cytotoxic-and-antioxidant-activities-of-the-jerusalem-balsams-using-chemometric-methods https://www.kozielewicz.com/publications/27151-antioxidant-cytotoxic-and-antiproliferative-activities-and-total-polyphenol-contents-of-the-extracts-of-geissospermum-reticulatum-bark https://www.kozielewicz.com/publications/28752-cytotoxic-anti-radical-and-reducing-properties-of-ethanol-bark-extracts-of-geissospermum-reticulatum https://www.kozielewicz.com/publications/28751-novel-vitamin-d-analogues-cytotoxic-and-anti-proliferative-activity-against-a-diffuse-large-b-cell-lymphoma-cell-line-and-b-cells-from-healthy-donors https://www.kozielewicz.com/publications/27152-intramolecular-cyclization-of-nitroso-o-quinone-methides-a-theoretical-endoscopy-of-a-potentially-useful-innate-reclusive-reaction https://www.kozielewicz.com/publications/27156-arene-fused-1-2-oxazole-n-oxides-and-derivatives-the-impact-of-the-n-o-dipole-and-substitution-on-their-aromatic-character-and-reactivity-profile-can-it-be-a-useful-structure-in-synthesis-a-theoretical-insight https://www.kozielewicz.com/publications/27155-insights-into-mechanism-of-anticancer-activity-of-pentacyclic-oxindole-alkaloids-of-uncaria-tomentosa-by-means-of-a-computational-reverse-virtual-screening-and-molecular-docking-approach https://www.kozielewicz.com/publications/27154-nitroso-o-quinone-methides-potent-intermediates-in-organic-chemistry-and-biology-the-impact-of-the-no-group-on-their-structure-and-reactivity-profile-a-theoretical-insight https://www.kozielewicz.com/projects/3013-analysis-of-the-role-of-orphan-gpcrs-in-cancer https://www.kozielewicz.com/projects/3014-investigations-into-orphan-gpcrs-as-regulators-of-metabolism https://www.kozielewicz.com/projects/3015-understanding-the-pharmacology-of-smoothened https://www.kozielewicz.com/people/2273-pawel-kozielewicz https://www.kozielewicz.com/people/4895-farouk-ghanem https://www.kozielewicz.com/people/4897-rhiannon-skye-kozel https://www.kozielewicz.com/people/5378-laura-jahrstorfer https://www.kozielewicz.com/people/5978-patryk-wesolowski https://www.kozielewicz.com/posts/3681-gpr61-in-severe-obesity-publication-in-molecular-pharmacology https://www.kozielewicz.com/posts/3328-publication-on-gpcrs-in-blood-cancers https://www.kozielewicz.com/pages/4781-collaborations https://www.kozielewicz.com/pages/4779-funding https://www.kozielewicz.com/pages/4777-people https://www.kozielewicz.com/pages/4776-projects