Molecular pharmacology of GPCRs

Welcome to the website of a newly-formed Molecular Pharmacology of G protein-coupled receptors research team. We are located at Karolinska Institutet and are a part of the Schulte lab.

We are interested in understanding the role of GPCRs in health and disease, with a focus on cancer and obesity. Of particular interest to us are understudied orphan GPCRs. These receptors bear untapped therapeutic potential and a lof of them are highly expressed or mutated in these diseases.

To shed light on the functions of orphan GPCRs in these conditions, we aim to employ an integrative approach. We will study these proteins in different systems, ranging from HEK293 cells to patients' samples, and investigate phenomena at different levels: from receptor conformational changes to impact on cell phenotype. Our methodologies include but are not limited to:
  • Bioluminescence resonance energy transfer (BRET)
  • CRISPR-Cas9 genome editing
  • Molecular modelling with ligand docking and molecular dynamics simulations
  • Proximal labelling techniques
  • Analysis of large RNAseq datasets
Please have a look at our projects and do not hesitate to get in touch about anything related to joining the group, potential project proposals, collaborations and financing our research.

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