Publications


New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer.


C. Espinosa-Bustos, J. Bertrand, Alondra Villegas-Menares, Simón Guerrero, L. Di Marcotullio, Shirin Navacci, Gunnar Schulte, P. Kozielewicz, Nicolas Bloch, Valentina Villela, Margot Paulino, Marcelo J. Kogan, Jorge Cantero, Cristian O Salas

Bioorganic chemistry (Print), 2024


Frizzleds act as dynamic pharmacological entities.


Gunnar Schulte, Magdalena M. Scharf, J. Bous, Jan Hendrik Voss, Lukas Grätz, P. Kozielewicz

TIPS - Trends in Pharmacological Sciences, 2024


Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7.


Julia Kinsolving, Julien Bous, P. Kozielewicz, Sara Košenina, Rawan Shekhani, Lukas Grätz, G. Masuyer, Yuankai Wang, P. Stenmark, Min Dong, Gunnar Schulte

Cell Reports, 2024


Progress on the development of Class A GPCR-biased ligands.


Paula Morales, Magdalena M Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K Hansen, Nadine Jagerovic, Jan Jakubík, György M Keserű, Dóra Judit Kiss, P. Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo-Abreu, Gemma Navarro, Rubén Prieto-Díaz, M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, L. Wingler

British Journal of Pharmacology, 2024


WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction


Carl-Fredrik Bowin, P. Kozielewicz, Lukas Grätz, Maria Kowalski-Jahn, Hannes Schihada, G. Schulte

Science Signaling, 2023


Class Frizzled GPCRs in GtoPdb v.2023.1 Class Frizzled GPCRs in GtoPdb v.2023.1


E. Arthofer, J. Dijksterhuis, Lukas Grätz, B. Hot, P. Kozielewicz, M. Lauth, J. Olofsson, J. Petersen, Tilman Polonio, G. Schulte, Kateřina Straková, Jana Valnohova, Shane C. Wright

2023


NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of WNT-3A to endogenous Frizzled 7 in a colorectal cancer model.


Lukas Grätz, J. J. Sajkowska-Kozielewicz, Janine Wesslowski, Julia Kinsolving, L. Bridge, Katja Petzold, G. Davidson, G. Schulte, P. Kozielewicz

British Journal of Pharmacology, 2023


Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations


Lukas Grätz, Maria Kowalski-Jahn, Magdalena M. Scharf, P. Kozielewicz, Michael Jahn, J. Bous, N. Lambert, D. Gloriam, G. Schulte

Nature Communications, 2023


The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors


Stephen P H Alexander, A. Christopoulos, Anthony P Davenport, E. Kelly, A. Mathie, John A Peters, E. Veale, J. Armstrong, E. Faccenda, S. Harding, J. Davies, M. Abbracchio, George Abraham, Alexander Agoulnik, Wayne Alexander, Khaled A. Al‐Hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross A. D. Bathgate, Jean‐Martin Beaulieu, Annette G. Beck-Sickinger, Maik Behrens, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, V. Blaho, Franc¸ois Boulay, Corinne Bousquet, H. Bräuner‐Osborne, Geoffrey Burnstock, Girolamo Calo’, Justo P. Castaño, K. J. Catt, S. Ceruti, P. Chazot, Chia Nan, Bice Chini, Jerold Chun, A. Cianciulli, Olivier Civelli, L. Clapp, Réjean Couture, Helen M. Cox, Z. Csaba, Claes Dahlgren, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, E. Filardo, Tung Fong, M. Fumagalli, R. Gainetdinov, Michael L Garelja, Marc Gasparo, Craig Gerard, M. Gershengorn, Fernand Junior Gobeil, T. Goodfriend, C. Goudet, Lukas Grätz, K. Gregory, A. L. Gundlach, Jörg Hamann, Julien Hanson, R. Hauger, Deborah L. Hay, A. Heinemann, D. Herr, M. Hollenberg, N. Holliday, M. Horiuchi, D. Hoyer, László Hunyady, Ahsan Husain, A. P. IJzerman, Tadashi Inagami, Kenneth A. Jacobson, R. Jensen, Ralf Jockers, Deepa Jonnalagadda, S. Karnik, K. Kaupmann, Jacqueline R. Kemp, Charles Kennedy, Yasuyuki Kihara, Takio Kitazawa, Paweł Kozielewicz, H. Kreienkamp, J. Kukkonen, T. Langenhan, D. Larhammar, K. Leach, D. Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Xaria X. Li, S. Lolait, A. Lupp, Robyn G. C. Macrae, J. Maguire, D. Malfacini, J. Mazella, C. McArdle, S. Melmed, Martin C. Michel, Laurence J. Miller, V. Mitolo, B. Mouillac, Christa E. Müller, P. M. Murphy, J. Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, A. O'Carroll, Stefan Offermanns, M. Panaro, Marc Parmentier, R. Pertwee, Jean-Philippe Pin, E. Prossnitz, Mark T. Quinn, R. Ramachandran, Manisha Ray, R. Reinscheid, P. Rondard, G. Rovati, C. Ruzza, Gareth J Sanger, Torsten Schöneberg, G. Schulte, Stefan Schulz, D. Segaloff, Charles N. Serhan, K. D. Singh, Craig M. Smith, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie Tan, D. Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan C. Tirupula, L. Toll, G. Tulipano, Hamiyet Unal, Thomas Unger, C. Valant, P. Vanderheyden, D. Vaudry, H. Vaudry, J. Vilardaga, Christopher Walker, Ji Ming Wang, Donald T. Ward, Hans-Juergen Wester, G. Willars, Tom Lloyd Williams, Trent M. Woodruff, Chengcan Yao, Richard D. Ye

British Journal of Pharmacology, 2023


Residue 6.43 defines receptor function in class F GPCRs


Ainoleena Turku, Hannes Schihada, P. Kozielewicz, Carl-Fredrik Bowin, G. Schulte

Nature Communications, 2021


Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs


Lu Xu, Bo Chen, Hannes Schihada, Shane C. Wright, Ainoleena Turku, Yiran Wu, G. Han, Maria Kowalski-Jahn, P. Kozielewicz, Carl-Fredrik Bowin, Xianjun Zhang, Chao Li, M. Bouvier, G. Schulte, Fei Xu

Cell Research, 2021


Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments


P. Kozielewicz, Rawan Shekhani, Stefanie Moser, Carl-Fredrik Bowin, Janine Wesslowski, G. Davidson, G. Schulte

ACS Pharmacology & Translational Science, 2021


THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors


Stephen P. H. Alexander, A. Christopoulos, A. Davenport, E. Kelly, A. Mathie, J. A. Peters, E. Veale, J. Armstrong, E. Faccenda, S. Harding, Adam J. Pawson, C. Southan, J. Davies, M. Abbracchio, Wayne Alexander, Khaled Al-hosaini, M. Bäck, N. Barnes, R. Bathgate, J. Beaulieu, K. Bernstein, B. Bettler, N. Birdsall, V. Blaho, F. Boulay, C. Bousquet, H. Bräuner‐Osborne, G. Burnstock, G. Calo’, J. Castaño, K. Catt, S. Ceruti, P. Chazot, N. Chiang, B. Chini, J. Chun, A. Cianciulli, O. Civelli, L. Clapp, R. Couture, Z. Csaba, C. Dahlgren, G. Dent, K. D. Singh, S. Douglas, P. Dournaud, S. Eguchi, E. Escher, E. Filardo, T. Fong, M. Fumagalli, R. Gainetdinov, M. Gasparo, C. Gerard, M. Gershengorn, F. Gobeil, T. Goodfriend, C. Goudet, K. Gregory, A. Gundlach, J. Hamann, J. Hanson, R. Hauger, D. Hay, A. Heinemann, M. Hollenberg, N. Holliday, M. Horiuchi, D. Hoyer, L. Hunyady, A. Husain, A. IJzerman, T. Inagami, K. Jacobson, R. Jensen, R. Jockers, Deepa Jonnalagadda, S. Karnik, K. Kaupmann, Jacqueline R. Kemp, C. Kennedy, Y. Kihara, T. Kitazawa, P. Kozielewicz, H. Kreienkamp, J. Kukkonen, T. Langenhan, K. Leach, D. Lecca, John D. Lee, S. Leeman, J. Leprince, Xaria X. Li, Thomas L. Williams, S. Lolait, A. Lupp, Robyn G. C. Macrae, J. Maguire, J. Mazella, C. McArdle, S. Melmed, M. Michel, L. Miller, V. Mitolo, B. Mouillac, C. Müller, Philip Murphy, J. Nahon, T. Ngo, X. Norel, Duuamene Nyimanu, A. O'Carroll, S. Offermanns, M. Panaro, M. Parmentier, R. Pertwee, J. Pin, E. Prossnitz, M. Quinn, R. Ramachandran, Manisha Ray, R. Reinscheid, P. Rondard, G. Rovati, C. Ruzza, G. Sanger, T. Schöneberg, G. Schulte, S. Schulz, D. Segaloff, C. Serhan, Leigh A. Stoddart, Y. Sugimoto, R. Summers, V. P. Tan, D. Thal, Walters Thomas, P. Timmermans, Kalyan C. Tirupula, G. Tulipano, Hamiyet Unal, T. Unger, C. Valant, P. Vanderheyden, D. Vaudry, H. Vaudry, J. Vilardaga, C. Walker, Ji Ming Wang, D. Ward, H. Wester, G. Willars, T. Woodruff, Chengcan Yao, R. Ye

British Journal of Pharmacology, 2021


Mitochondrial protein biogenesis in the synapse is supported by local translation


Bożena Kuźniewska, D. Cysewski, Michał Wasilewski, Paulina Sakowska, J. Miłek, Tomasz M. Kuliński, M. Winiarski, P. Kozielewicz, E. Knapska, M. Dadlez, A. Chacińska, A. Dziembowski, M. Dziembowska

EMBO Reports, 2020


eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled


Janine Wesslowski, P. Kozielewicz, Xianxian Wang, Haijun Cui, Hannes Schihada, Dominique Kranz, Pradhipa Karuna M, P. Levkin, J. Gross, M. Boutros, G. Schulte, G. Davidson

Journal of Biological Chemistry, 2020


Geissospermiculatine, a New Alkaloid from Geissospermum reticulatum Bark


J. J. Sajkowska-Kozielewicz, P. Kozielewicz, K. Makarova, Marcin Stocki, N. Barnes, K. Paradowska

Molecules, 2020


Structural insight into small molecule action on Frizzleds


P. Kozielewicz, Ainoleena Turku, Carl-Fredrik Bowin, J. Petersen, J. Valnohova, Maria Consuelo Alonso Cañizal, Yuki Ono, A. Inoue, C. Hoffmann, G. Schulte

Nature Communications, 2020


Molecular Pharmacology of Class F Receptor Activation


P. Kozielewicz, Ainoleena Turku, G. Schulte

Molecular Pharmacology, 2020


Mitochondria biogenesis in the synapse is supported by local translation


Bożena Kuźniewska, D. Cysewski, Michał Wasilewski, Paulina Sakowska, J. Miłek, Tomasz M. Kuliński, P. Kozielewicz, M. Dadlez, A. Chacińska, A. Dziembowski, M. Dziembowska

bioRxiv, 2019


A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection


Shane C. Wright, P. Kozielewicz, Maria Kowalski-Jahn, J. Petersen, Carl-Fredrik Bowin, G. Slodkowicz, M. Marti-Solano, D. Rodríguez, B. Hot, Najeah Okashah, Kateřina Straková, J. Valnohova, M. Madan Babu, N. Lambert, Jens Carlsson, G. Schulte

Nature Communications, 2019


N‐glycosylation and expression in human tissues of the orphan GPR61 receptor


P. Kozielewicz, Hatun A. Alomar, Syaratul Yusof, G. Grafton, A. Cooper, S. Curnow, J. Ironside, H. Pall, N. Barnes

FEBS Open Bio, 2017


2, 2′‐Dihydroxybenzophenones and Derivatives. Efficient Synthesis and Structure Endoscopy by DFT and NMR. Credentials as Potent Antiinflammatory Agents.


Demeter Tzeli, P. Kozielewicz, M. Zervou, C. Potamitis, Katerina Kokkotou, Benedikt Rak, A. Petrou, E. Tsolaki, A. Gavalas, A. Geronikaki, I. Petsalakis, P. Tsoungas

2016


Analysis of impact of cytotoxic and antioxidant activities of the Jerusalem Balsams using chemometric methods


JJ Sajkowska-Kozielewicz, P. Kozielewicz, K. Makarova, I. Wawer, K. Paradowska

Planta Medica, 2016


Antioxidant, Cytotoxic, and Antiproliferative Activities and Total Polyphenol Contents of the Extracts of Geissospermum reticulatum Bark


J. J. Sajkowska-Kozielewicz, P. Kozielewicz, N. Barnes, I. Wawer, K. Paradowska

Oxidative Medicine and Cellular Longevity, 2016


Cytotoxic, anti-radical and reducing properties of ethanol bark extracts of Geissospermum reticulatum


JJ Sajkowska-Kozielewicz, P. Kozielewicz, NM Barnes, I. Wawer, K. Paradowska

Planta Medica, 2016


Novel vitamin D analogues; cytotoxic and anti-proliferative activity against a diffuse large B-cell lymphoma cell line and B-cells from healthy donors


Paweł Kozielewicz, G. Grafton, A. Kutner, S. Curnow, J. Gordon, Nicholas M. Barnes, Paweł Kozielewicz, S. Curnow

Journal of Steroid Biochemistry and Molecular Biology, 2016


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