THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Journal article

Stephen P. H. Alexander, A. Christopoulos, A. Davenport, E. Kelly, A. Mathie, J. A. Peters, E. Veale, J. Armstrong, E. Faccenda, S. Harding, Adam J. Pawson, C. Southan, J. Davies, M. Abbracchio, Wayne Alexander, Khaled Al-hosaini, M. Bäck, N. Barnes, R. Bathgate, J. Beaulieu, K. Bernstein, B. Bettler, N. Birdsall, V. Blaho, F. Boulay, C. Bousquet, H. Bräuner‐Osborne, G. Burnstock, G. Calo’, J. Castaño, K. Catt, S. Ceruti, P. Chazot, N. Chiang, B. Chini, J. Chun, A. Cianciulli, O. Civelli, L. Clapp, R. Couture, Z. Csaba, C. Dahlgren, G. Dent, K. D. Singh, S. Douglas, P. Dournaud, S. Eguchi, E. Escher, E. Filardo, T. Fong, M. Fumagalli, R. Gainetdinov, M. Gasparo, C. Gerard, M. Gershengorn, F. Gobeil, T. Goodfriend, C. Goudet, K. Gregory, A. Gundlach, J. Hamann, J. Hanson, R. Hauger, D. Hay, A. Heinemann, M. Hollenberg, N. Holliday, M. Horiuchi, D. Hoyer, L. Hunyady, A. Husain, A. IJzerman, T. Inagami, K. Jacobson, R. Jensen, R. Jockers, Deepa Jonnalagadda, S. Karnik, K. Kaupmann, Jacqueline R. Kemp, C. Kennedy, Y. Kihara, T. Kitazawa, P. Kozielewicz, H. Kreienkamp, J. Kukkonen, T. Langenhan, K. Leach, D. Lecca, John D. Lee, S. Leeman, J. Leprince, Xaria X. Li, Thomas L. Williams, S. Lolait, A. Lupp, Robyn G. C. Macrae, J. Maguire, J. Mazella, C. McArdle, S. Melmed, M. Michel, L. Miller, V. Mitolo, B. Mouillac, C. Müller, Philip Murphy, J. Nahon, T. Ngo, X. Norel, Duuamene Nyimanu, A. O'Carroll, S. Offermanns, M. Panaro, M. Parmentier, R. Pertwee, J. Pin, E. Prossnitz, M. Quinn, R. Ramachandran, Manisha Ray, R. Reinscheid, P. Rondard, G. Rovati, C. Ruzza, G. Sanger, T. Schöneberg, G. Schulte, S. Schulz, D. Segaloff, C. Serhan, Leigh A. Stoddart, Y. Sugimoto, R. Summers, V. P. Tan, D. Thal, Walters Thomas, P. Timmermans, Kalyan C. Tirupula, G. Tulipano, Hamiyet Unal, T. Unger, C. Valant, P. Vanderheyden, D. Vaudry, H. Vaudry, J. Vilardaga, C. Walker, Ji Ming Wang, D. Ward, H. Wester, G. Willars, T. Woodruff, Chengcan Yao, R. Ye
British Journal of Pharmacology, 2021

Semantic Scholar DOI PubMed


APA   Click to copy
Alexander, S. P. H., Christopoulos, A., Davenport, A., Kelly, E., Mathie, A., Peters, J. A., … Ye, R. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors. British Journal of Pharmacology.

Chicago/Turabian   Click to copy
Alexander, Stephen P. H., A. Christopoulos, A. Davenport, E. Kelly, A. Mathie, J. A. Peters, E. Veale, et al. “THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G Protein‐Coupled Receptors.” British Journal of Pharmacology (2021).

MLA   Click to copy
Alexander, Stephen P. H., et al. “THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G Protein‐Coupled Receptors.” British Journal of Pharmacology, 2021.

BibTeX   Click to copy

  title = {THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors},
  year = {2021},
  journal = {British Journal of Pharmacology},
  author = {Alexander, Stephen P. H. and Christopoulos, A. and Davenport, A. and Kelly, E. and Mathie, A. and Peters, J. A. and Veale, E. and Armstrong, J. and Faccenda, E. and Harding, S. and Pawson, Adam J. and Southan, C. and Davies, J. and Abbracchio, M. and Alexander, Wayne and Al-hosaini, Khaled and Bäck, M. and Barnes, N. and Bathgate, R. and Beaulieu, J. and Bernstein, K. and Bettler, B. and Birdsall, N. and Blaho, V. and Boulay, F. and Bousquet, C. and Bräuner‐Osborne, H. and Burnstock, G. and Calo’, G. and Castaño, J. and Catt, K. and Ceruti, S. and Chazot, P. and Chiang, N. and Chini, B. and Chun, J. and Cianciulli, A. and Civelli, O. and Clapp, L. and Couture, R. and Csaba, Z. and Dahlgren, C. and Dent, G. and Singh, K. D. and Douglas, S. and Dournaud, P. and Eguchi, S. and Escher, E. and Filardo, E. and Fong, T. and Fumagalli, M. and Gainetdinov, R. and Gasparo, M. and Gerard, C. and Gershengorn, M. and Gobeil, F. and Goodfriend, T. and Goudet, C. and Gregory, K. and Gundlach, A. and Hamann, J. and Hanson, J. and Hauger, R. and Hay, D. and Heinemann, A. and Hollenberg, M. and Holliday, N. and Horiuchi, M. and Hoyer, D. and Hunyady, L. and Husain, A. and IJzerman, A. and Inagami, T. and Jacobson, K. and Jensen, R. and Jockers, R. and Jonnalagadda, Deepa and Karnik, S. and Kaupmann, K. and Kemp, Jacqueline R. and Kennedy, C. and Kihara, Y. and Kitazawa, T. and Kozielewicz, P. and Kreienkamp, H. and Kukkonen, J. and Langenhan, T. and Leach, K. and Lecca, D. and Lee, John D. and Leeman, S. and Leprince, J. and Li, Xaria X. and Williams, Thomas L. and Lolait, S. and Lupp, A. and Macrae, Robyn G. C. and Maguire, J. and Mazella, J. and McArdle, C. and Melmed, S. and Michel, M. and Miller, L. and Mitolo, V. and Mouillac, B. and Müller, C. and Murphy, Philip and Nahon, J. and Ngo, T. and Norel, X. and Nyimanu, Duuamene and O'Carroll, A. and Offermanns, S. and Panaro, M. and Parmentier, M. and Pertwee, R. and Pin, J. and Prossnitz, E. and Quinn, M. and Ramachandran, R. and Ray, Manisha and Reinscheid, R. and Rondard, P. and Rovati, G. and Ruzza, C. and Sanger, G. and Schöneberg, T. and Schulte, G. and Schulz, S. and Segaloff, D. and Serhan, C. and Stoddart, Leigh A. and Sugimoto, Y. and Summers, R. and Tan, V. P. and Thal, D. and Thomas, Walters and Timmermans, P. and Tirupula, Kalyan C. and Tulipano, G. and Unal, Hamiyet and Unger, T. and Valant, C. and Vanderheyden, P. and Vaudry, D. and Vaudry, H. and Vilardaga, J. and Walker, C. and Wang, Ji Ming and Ward, D. and Wester, H. and Willars, G. and Woodruff, T. and Yao, Chengcan and Ye, R.}


The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (, which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at G protein‐coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.


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