Journal article
E. Arthofer, J. Dijksterhuis, Lukas Grätz, B. Hot, P. Kozielewicz, M. Lauth, J. Olofsson, J. Petersen, Tilman Polonio, G. Schulte, Kateřina Straková, Jana Valnohova, Shane C. Wright
2023
2023
Semantic Scholar
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APA
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Arthofer, E., Dijksterhuis, J., Grätz, L., Hot, B., Kozielewicz, P., Lauth, M., … Wright, S. C. (2023). Class Frizzled GPCRs in GtoPdb v.2023.1 Class Frizzled GPCRs in GtoPdb v.2023.1.
Chicago/Turabian
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Arthofer, E., J. Dijksterhuis, Lukas Grätz, B. Hot, P. Kozielewicz, M. Lauth, J. Olofsson, et al. “Class Frizzled GPCRs in GtoPdb V.2023.1 Class Frizzled GPCRs in GtoPdb V.2023.1” (2023).
MLA
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Arthofer, E., et al. Class Frizzled GPCRs in GtoPdb V.2023.1 Class Frizzled GPCRs in GtoPdb V.2023.1. 2023.
BibTeX Click to copy
@article{e2023a,
title = {Class Frizzled GPCRs in GtoPdb v.2023.1 Class Frizzled GPCRs in GtoPdb v.2023.1},
year = {2023},
author = {Arthofer, E. and Dijksterhuis, J. and Grätz, Lukas and Hot, B. and Kozielewicz, P. and Lauth, M. and Olofsson, J. and Petersen, J. and Polonio, Tilman and Schulte, G. and Straková, Kateřina and Valnohova, Jana and Wright, Shane C.}
}
Abstract
Abstract Receptors of the Class Frizzled (FZD, nomenclature as agreed by the nomenclature as agreed by the NC-IUPHARNC-IUPHAR subcommittee on the subcommittee on the Class Frizzled GPCRs [ Class Frizzled GPCRs [180180]] ), are GPCRs originally identified in Drosophila [20], which are highly conserved across species. While SMO shows structural resemblance to the 10 FZDs, it is functionally separated as it is involved in the Hedgehog signaling pathway [180]. SMO exerts its effects by activating heterotrimeric G proteins or stabilization of GLI by sequestering catalytic PKA subunits [186, 6, 58]. While SMO itself is bound by sterols and oxysterols [27, 94], FZDs are activated by WNTs, which are cysteine-rich lipoglycoproteins with fundamental functions in ontogeny and tissue homeostasis. FZD signalling was initially divided into two pathways, being either dependent on the accumulation of the transcription regulator β-catenin or being β-catenin-independent (often referred to as canonical vs. non-canonical WNT/FZD signalling, respectively). WNT stimulation of FZDs can, in cooperation with the low density lipoprotein receptors LRP5 (O75197) and LRP6 (
